L-arginine
L-arginine is a chemical building block called “an amino acid.” It is obtained from the diet and is necessary for the body to make proteins. L-arginine is found in red meat, poultry, fish, and dairy products. It can also be made in a laboratory and used as medicine.
L-arginine is used for heart and blood vessel conditions including congestive heart failure (CHF), chest pain, high blood pressure, high cholesterol, heart surgery, recovery after heart transplant, heart attack, and coronary artery disease. L-arginine is also used for recurrent pain in the legs due to blocked arteries (intermittent claudication), decreased mental capacity in the elderly (senile dementia), erectile dysfunction (ED), altitude sickness, nitrate tolerance, diabetes, diabetic nerve pain, muscular dystrophy, kidney toxicity from cyclosporine, valproic acid toxicity, anthracycline toxicity, kidney disease, tuberculosis, critical illness, head and neck cancer, obesity, ovary disease (polycystic ovary syndrome), pressure ulcers, respiratory infections, sickle cell disease, stress, and male infertility.
Some people use L-arginine for preventing the common cold, improving kidney function after a kidney transplant, high blood pressure during pregnancy (pre-eclampsia), improving athletic performance, boosting the immune system, and preventing inflammation and tissue death of the digestive tract in premature infants (necrotizing enterocolitis) and improving growth of a small baby within the uterus.
L-arginine is used in combination with a number of over-the-counter and prescription medications for various conditions. For example, L-arginine is used along with ibuprofen for migraine headaches; with conventional chemotherapy drugs for treating breast cancer; with other amino acids for treating weight loss in people with AIDS, for improving wound healing in people with diabetes, and for preventing skin inflammation because of radiation; and with fish oil and other supplements for reducing infections, improving wound healing, and shortening recovery time after surgery.
Some people apply L-arginine to the skin to speed wound healing, healing of small rips of the anus, and for increasing blood flow to cold hands and feet, especially in people with diabetes. It is also used as a cream for sexual problems in both men and women. Arginine has also been used for dental caries and dental hypersensitivity.
L-arginine has been injected into the vein for recurrent pain in the legs due to blocked arteries (intermittent claudication), reduced blood flow to the limbs (peripheral artery disease), for detecting growth hormone deficiency, disease due to defective mitochondria (mitochondrial encephalomyopathies), chest pain due to gastric problems, restenosis, kidney transplant, nutrition for the critically ill, metabolic acidosis, and increased blood pressure in the artery of the lungs (pulmonary hypertension) in newborns. It is also used to improve the growth of a small baby within the uterus.
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L-Arginine Supplements Guide
What is L-Arginine?
L-Arginine is the supplemental version of arginine; that amazing amino acid you just read a little bit about. Arginine can be found naturally in foods high in protein, such as meat, nuts, fish, and soybeans.
It is also naturally produced within the human body. L-Arginine offers the samebenefits as arginine, it is just the concentrated supplemental version. There are twenty different versions of Arginine, and the “L” version is the one that is used for supplements, and is the only one that should be used as a supplement, because it is the “free form” version.
This amino acid was first isolated from a lupine seedling in 1886. It was discovered to trigger protein building within the human body. Because of this, L-Arginine has been studied as a supplement for bodybuilding, healing wounds, enhancing sperm production, and reducing bodily tissue waste. It has also been studied for cardiovascular disease treatment and prevention.
L-Arginine helps the endothelial cells produce nitric oxide, which is necessary for maintaining healthy blood circulation. The endothelial cells are in the lining of all the blood vessels in your body. Nitric oxide is a gas that is a byproduct of L-Arginine and produced by both plants and animals. Understanding what nitric oxide does helps you to understand the benefits of L-Arginine, because arginine (or L-Arginine) is necessary for nitric oxide production.
What Are L-Arginine Supplements?
L-arginine supplements are exactly what they imply. They supplement your diet with arginine in the form of L-Arginine, one of the twenty different types of this key amino acid. The average American diet consists of around 5 g of arginine, usually derived from not-so-healthy red meat. Better natural sources for your health includes fish, tofu, and nuts.
The issue is that it is recommended for your health to consume 6 to 9 g of L-Arginine daily. In order to consume this much, you would have to eat 2.5 pounds of tofu, or a half pound of tuna! Top arginine supplements allow a person to obtain the recommended amount, without eating large amounts of red meat, or eating large amounts of other protein sources.
Benefits of L-Arginine
According to WebMD, arginine, which is also known as L-arginine, is involved in a different functions in your body. WebMD also lists a few other benefits and also some concerns.
L-Arginine also plays a role in the function of the immune system, and this is because it not only stimulates protein production, but is also required for the production of white blood cells. This means that L-Arginine can be used to help people recover from illness and cancer treatments, which take a huge toll on the immune system.
Besides surgical recovery, it is commonly taken to prevent colds and prevent and treat infections. The combination of protein production stimulation and white blood cell production stimulation makes the best arginine supplements powerful recovery tools.
Arginine supplements are also used to increase production of human growth hormones in the body. These hormones include amino acids (including creatine, L-proline, and L-glutamine) and prolactin. It improves metabolic health by allowing more glucose to enter the cells, which means it helps the body burn fat. It also improves muscle strength.
Because arginine helps to increase human growth hormones, it has profoundly positive effects on the metabolism, and skeletal-muscular system.
Studies have also been conducted on L-Arginine’s impact on type II diabetes. In one study, it was discovered that L-Arginine “evoked large increases in insulin secretion from the pancreas of diabetic rat.” This suggests that it could have the same effect on humans, because rats can be from 85% to 99% genetically identical to humans. Currently, the evidence suggests that L-Arginine may stimulate insulin production.
Who May Benefit from L-Arginine?
* Athletes and fitness enthusiasts – L-Arginine supplements are a favorite in the athletic community because of the nitric oxide it creates in the body. Nitric oxide has been shown to reduce muscle fatigue, improve endurance levels, increase energy, speed up recovery rates, and increased use of glucose (which means burning body fat). On top of all of these naturally enhancing health benefits, L-Arginine has been shown to trigger the production of proteins in the body. It also has been shown to increase lean muscle mass. So, arginine benefits help you burn fat, build muscle, and improve performance.
* Stress – When combined with L-lysine, L-Arginine was shown to reduce symptoms of anxiety. It may reduce symptoms of anxiety alone as well, but more research must be done to confirm this. Its ability to reduce high blood pressure and open red blood cells indicates that it has stress-relieving properties.
* Sufferers of heart and blood vessel conditions – Congestive heart failure (CHF), chest pain, coronary artery disease, and leg pain due to blocked arteries are all examples of conditions that can be aided through L-Arginine supplementation. The nitric oxide that L-Arginine helps create in the body helps to improve blood circulation and relax blood vessels.
* Aging individuals – Aging individuals can greatly benefit from L-arginine because of the nitric oxide that it is capable of creating through the endothelial cells. Endothelial cells are the linings of our arteries and our blood vessels, and these cells need arginine in order to create enough nitric oxide to maintain healthy blood circulation. Research suggests that our ability to produce nitric oxide decreases as we age, and taking arginine supplements can possibly counteract that.
* Migraine sufferers – Migraines are a neurovascular disorder, and L-Arginine improves vascular health. To translate, this means that migraines are partially caused by constricting blood vessels, and L-Arginine helps dilate blood vessels. This means that for some migraine sufferers, L-Arginine could be beneficial in reducing symptoms.
* Vegans and vegetarians – Sometimes it is hard with a vegan diet to ensure that you are eating enough dietary protein. An L-Arginine supplement can help ensurethat your body is getting enough amino acids, which are the building blocks of proteins.
Are There Any Side Effects?
The side effects of an L-Arginine supplement occurs when there is a large dose taken at once, or when it interacts with preexisting conditions or pharmaceutical drugs. Some of the preexisting conditions that L-Arginine may worsen include allergies and asthma, herpes, cirrhosis, and low blood pressure.
L-Arginine should not be given to children without speaking to a doctor first. It may increase the risk of death from a heart attack in aging individuals. More than a dose of 10 g can cause diarrhea and gas.
What Interacts with L-Arginine?
L-Arginine can interact with pharmaceutical drugs, and here are some that should not be taken in conjunction with L-Arginine supplements:
* Antihypertensive drugs
* Nitroglycerine isosorbide (increases blood flow to the heart)
* Viagra
* High blood pressure medications
People who have high levels of arginine in their bodies should avoid supplementing themselves with more L-Arginine.
How to Take L-Arginine
Safe methods of taking L-Arginine supplements include taking it by mouth, shot, or application to the skin. The most common way to supplement is by mouth, in the form of an L-Arginine capsule, pill or powder.
Arginine supplements do not have to be consumed with food, but they may be better absorbed with food. Powders are more easily assimilated in the digestive system than pills.
What to Look for in a Good Arginine Product
* Company reputation – It is important that you are purchasing your supplements from a trustworthy and established company. Sometimes established means that they have been in the industry for more than twenty years, but sometimes it means that they are certified manufacturing facilities that have been government tested. A great way to make sure that the company is trustworthy is to look for a cGMP certification, meaning that they have current Good Manufacturing Practices. Ultimately, make sure that you research the company before you make a purchase.
* Amount of L-Arginine per serving – In the world of supplements, you have to make sure you are getting the most bang for your buck. Knowing the effective doses of the particular supplement you are looking for is crucial. For L-Arginine, anything less than 5 g in a day may not be effective. It also depends on your purpose for supplementing.
* Additives and Preservatives – some L-Arginine supplements contain additives, fillers, and preservatives. This is not always a drawback, because in some cases they are there to help the body absorb the L-Arginine. In other cases, it is just there to take up space. Would you rather pay for the best arginine supplements, or primarily fillers?
* Tested Ingredients – Some supplements use agmatine instead of L-Arginine. Agmatine is a chemical derivative of L-Arginine that acts as a neurotransmitter. It is good to look into how much research has been conducted on the ingredients in your supplements.
* Added vitamins and amino acids – This is mostly a personal preference. Some L-Arginine supplements contain additional vitamins and amino acids which compliment and enhance the benefits of arginine supplements. If there is still a sufficient dose of L-Arginine in the supplement, then this can be a major benefit! If you are looking for pure L-Arginine, then steer clear of longer ingredients lists.
* Assimilation – Assimilation refers to how well the body can absorb a supplement. Generally speaking, a powder that is mixed in water is more easily assimilated than a pill.
- Published in Blog, Fitness, supplements