GLOSSARY

Folate Status Table

Micronutrient biomarkers differ in sensitivity, specificity and preanalytical requirements; laboratory intervals are not personal intake goals.

Folate Status Folate-related status interpreted using the appropriate measurement, intake history and physiological context.

Nutrient status reflects intake, absorption, distribution, stores, losses and physiological demand. A normal blood concentration may not exclude depleted stores, while an abnormal result can have non-nutritional causes. Calcium in blood, for example, does not directly measure dietary calcium adequacy or skeletal reserves. Different nutrients require different assessment strategies. Select tests for a defined clinical question and interpret them with symptoms, diet, relevant disease and sampling conditions instead of ordering a broad panel and assuming every number is a performance target.

A recovery biomarker quantitatively relates to intake or expenditure under a specified balance model, whereas a concentration biomarker is influenced by absorption, metabolism and other factors. Predictive biomarkers use a calibrated relationship that may depend on the studied population. Distinguish intake biomarkers from markers of tissue status, function or disease. Blood, urine and tissue measurements answer different questions. Sampling conditions, recent exercise, hydration and inflammation can affect interpretation; no single biomarker provides a complete nutritional assessment or proves the cause of poor performance.

For example, a normal serum calcium result does not show that an athlete regularly eats enough calcium. Review food sources, the clinical question and any appropriate further assessment. Nutrient status and reported intake complement one another; neither should be forced to answer a question it cannot reliably resolve.