GLOSSARY

Zona Glomerulosa
The zona glomerulosa is the outer cortical zone and primarily produces aldosterone.

Distinct adrenal pathways

Adrenal zones differ in enzyme expression and regulatory inputs. ACTH strongly influences glucocorticoid pathways, whereas angiotensin II and potassium are major aldosterone regulators. Steroid binding, local conversion and clearance modify the relationship between gland output and blood concentration.

A distinction that matters

Angiotensin II and potassium provide major regulatory inputs, and CYP11B2 supports terminal synthesis.

Context for a result

Sampling time, illness, medicines, posture and sodium status matter differently for different adrenal tests. An exercise-associated rise is not itself a diagnosis. Persistent symptoms or abnormal biochemical patterns require the appropriate clinical assessment.