Testosterone Transport in Blood
Androgens and Male Reproductive Endocrinology
Testosterone Transport in Blood
Testosterone circulates bound to SHBG and albumin, with a smaller free fraction.
Production, transport and local action
Androgen action depends on central gonadotropin drive, gonadal production, binding proteins and tissue-specific metabolism. Conversion to DHT or estradiol changes the local signal. Receptor expression and cofactors determine how exposure becomes a response in each organ.
A distinction that matters
Carrier changes can alter total concentration without equivalent changes in free exposure.
Interpreting androgen status
Symptoms, repeated appropriately timed measurements and relevant LH, FSH and SHBG results help distinguish endocrine patterns. A transient exercise-associated change does not predict hypertrophy. Exogenous androgen exposure can suppress endogenous regulation and fertility despite high circulating concentrations.
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