GLOSSARY

Local lipid signaling

Lipid mediators are often produced on demand and act close to their source through receptor-specific pathways. Substrate availability, enzyme activity and local degradation determine the signal. A shared precursor does not give all products the same inflammatory or vascular function.

Specific considerations

Their mechanisms and measurement require careful experimental validation. Detecting a precursor or increasing omega-3 intake does not prove a clinically effective increase in every mediator.

Repair requires timing

Early inflammatory responses and later resolution support different stages of tissue recovery. A change in one circulating mediator does not establish improved repair or justify routine suppression of all inflammation after training.