Rapid Non-Genomic Androgen Signaling
Androgens and Male Reproductive Endocrinology
Rapid Non-Genomic Androgen Signaling
Rapid androgen-related responses can involve signaling that does not initially require new transcription.
Production, transport and local action
Androgen action depends on central gonadotropin drive, gonadal production, binding proteins and tissue-specific metabolism. Conversion to DHT or estradiol changes the local signal. Receptor expression and cofactors determine how exposure becomes a response in each organ.
Interpreting the mechanism
Mechanism and receptor identity require experimental evidence rather than inference from speed alone.
Interpreting androgen status
Symptoms, repeated appropriately timed measurements and relevant LH, FSH and SHBG results help distinguish endocrine patterns. A transient exercise-associated change does not predict hypertrophy. Exogenous androgen exposure can suppress endogenous regulation and fertility despite high circulating concentrations.
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