Protein Kinase C (PKC) Signaling
Hormone Receptors and Molecular Signaling
Protein Kinase C (PKC) Signaling
Protein kinase C comprises a family of serine–threonine kinases with different regulatory requirements. Several isoforms connect lipid messengers and calcium signals with secretion, transport, growth and other cellular responses.
Three broad groups
Conventional PKCs respond to DAG and calcium. Novel PKCs respond to DAG without the same calcium dependence. Atypical PKCs have distinct regulation and are not activated by DAG in the same manner.
Context determines the outcome
PKC can modify receptors, transport proteins and other signaling components. Its effect can strengthen one response while limiting another through feedback or pathway interactions.
Why the isoform matters
A statement that a hormone activates PKC is incomplete without the relevant cell and isoform. In metabolic studies, selected PKC pathways can be involved in altered insulin signaling, but this does not mean all PKC activity is harmful or that every isoform has the same physiological role.
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