Prostaglandins in Cervical Ripening
Endocrinology of Pregnancy, Parturition and Lactation
Prostaglandins in Cervical Ripening
Prostaglandins contribute to cervical extracellular-matrix remodeling and labor-related readiness.
Maternal, placental and fetal integration
Pregnancy changes hormone production, binding, clearance and target-tissue responsiveness. Maternal, placental and fetal tissues contribute different components. Expected laboratory patterns therefore depend on gestational stage and the analytical method, rather than nonpregnant reference values alone.
A distinction that matters
- Local production and receptor pathways interact with mechanical and inflammatory processes.
Transitions around birth
Placental delivery rapidly changes steroid exposure, while prolactin-related synthesis and oxytocin-mediated ejection support lactation. These are coordinated but distinct mechanisms. Clinical problems during pregnancy or postpartum require interpretation within their specific maternal and fetal context.
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