Prostaglandin Biosynthesis
Eicosanoids and Lipid Mediators
Prostaglandin Biosynthesis
Cyclooxygenase reactions convert arachidonic acid toward PGH2, which tissue-specific synthases direct into different prostanoids.
Local lipid signaling
Lipid mediators are often produced on demand and act close to their source through receptor-specific pathways. Substrate availability, enzyme activity and local degradation determine the signal. A shared precursor does not give all products the same inflammatory or vascular function.
A distinction that matters
The terminal enzyme repertoire helps determine the final biological product.
Repair requires timing
Early inflammatory responses and later resolution support different stages of tissue recovery. A change in one circulating mediator does not establish improved repair or justify routine suppression of all inflammation after training.
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