Prolactin Receptor and JAK2–STAT5 Signaling
Anterior Pituitary, Growth Hormone and Prolactin
Prolactin Receptor and JAK2–STAT5 Signaling
The prolactin receptor belongs to the cytokine receptor family and signals through associated kinases rather than intrinsic receptor tyrosine kinase activity. JAK2–STAT5 is an important downstream route.
From binding to transcription
Prolactin binding changes receptor organization and supports activation of JAK2 and STAT5-related gene regulation. Other signaling pathways also contribute in appropriate cells.
Tissue-dependent output
In mammary tissue, the pathway supports differentiation and milk-related gene expression. Receptor distribution and local regulatory partners shape actions elsewhere.
Functional boundary
A prolactin concentration does not directly quantify receptor activation in every tissue. The biological response depends on receptor state, downstream regulation and the broader reproductive hormonal environment.
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