GLOSSARY

Phospholipase A2
Phospholipase A2 enzymes hydrolyze the fatty acid at the sn-2 position of phospholipids, potentially releasing arachidonic acid for mediator synthesis. Different family members act in distinct cellular locations.

Local lipid signaling

Lipid mediators are often produced on demand and act close to their source through receptor-specific pathways. Substrate availability, enzyme activity and local degradation determine the signal. A shared precursor does not give all products the same inflammatory or vascular function.

A distinction that matters

• Cytosolic, secreted and calcium-independent forms have different regulation.
• The digestive pancreatic enzyme and intracellular mediator-related enzymes should not be treated as one interchangeable protein.

Repair requires timing

Early inflammatory responses and later resolution support different stages of tissue recovery. A change in one circulating mediator does not establish improved repair or justify routine suppression of all inflammation after training.