Luteinizing Hormone Regulation of Leydig Cells
Androgens and Male Reproductive Endocrinology
Luteinizing Hormone Regulation of Leydig Cells
LH stimulates Leydig-cell steroidogenesis through LH/hCG receptor signaling, promoting cholesterol delivery and steroidogenic activity.
Production, transport and local action
Androgen action depends on central gonadotropin drive, gonadal production, binding proteins and tissue-specific metabolism. Conversion to DHT or estradiol changes the local signal. Receptor expression and cofactors determine how exposure becomes a response in each organ.
Specific considerations
The response depends on receptor and enzymatic capacity.
Interpreting androgen status
Symptoms, repeated appropriately timed measurements and relevant LH, FSH and SHBG results help distinguish endocrine patterns. A transient exercise-associated change does not predict hypertrophy. Exogenous androgen exposure can suppress endogenous regulation and fertility despite high circulating concentrations.
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