Lipid Mediators in Muscle Repair
Eicosanoids and Lipid Mediators
Lipid Mediators in Muscle Repair
Lipid mediators coordinate inflammatory-cell recruitment, resolution and remodeling after muscle injury.
Local lipid signaling. Lipid mediators are often produced on demand and act close to their source through receptor-specific pathways. Substrate availability, enzyme activity and local degradation determine the signal. A shared precursor does not give all products the same inflammatory or vascular function.
Interpreting the mechanism. Their effects depend on stage and source; lowering every inflammatory signal is not equivalent to improving repair.
Repair requires timing. Early inflammatory responses and later resolution support different stages of tissue recovery. A change in one circulating mediator does not establish improved repair or justify routine suppression of all inflammation after training.
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