IL-6 Receptor Signaling
Myokines and Skeletal Muscle Endocrine Signaling
IL-6 Receptor Signaling
IL-6 signaling involves IL-6R and gp130, with classical and trans-signaling arrangements producing different contexts.
Evidence for muscle-derived signals
A candidate myokine requires evidence of muscle production and release. Endocrine action additionally requires biologically relevant delivery and a response at a distant target. Expression within muscle or an increase in blood alone does not establish this entire chain.
Specific considerations
Receptor distribution helps determine the responding cell population.
Interpreting exercise studies
Sampling time, muscle damage, other tissue sources and assay specificity affect measured exerkines. Animal or cell findings can identify mechanisms but do not guarantee a proven human performance benefit. Local action may be important even without a detectable circulating rise.
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