Growth Hormone Secretagogue Receptor
Gastrointestinal Hormones and Gut–Brain Communication
Growth Hormone Secretagogue Receptor
GHSR mediates classical acyl-ghrelin signaling and participates in GH secretion and appetite-related networks.
A network of nutrient signals
Gastrointestinal signaling combines direct nutrient sensing, enteric neural activity, endocrine release and vagal communication. Meal size, composition and gastric emptying affect the response. Several peptides can be released together, so one concentration cannot explain the entire postprandial state.
Specific considerations
Receptor expression, constitutive activity and ligand availability influence responses.
Appetite and exercise
An acute appetite-hormone change does not necessarily predict later food intake. Exercise duration, intensity, heat and carbohydrate availability can modify both secretion and symptoms. Measurements are most useful when linked with actual intake, tolerance and recovery.
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