GLOSSARY

Gonadotropin-Releasing Hormone Pulsatility
Pulsatile GnRH supports physiological gonadotropin secretion.

Production, transport and local action

Androgen action depends on central gonadotropin drive, gonadal production, binding proteins and tissue-specific metabolism. Conversion to DHT or estradiol changes the local signal. Receptor expression and cofactors determine how exposure becomes a response in each organ.

Interpreting the mechanism

Frequency and amplitude interact with feedback, while continuous exposure can reduce responsiveness rather than reproduce normal reproductive stimulation.

Interpreting androgen status

Symptoms, repeated appropriately timed measurements and relevant LH, FSH and SHBG results help distinguish endocrine patterns. A transient exercise-associated change does not predict hypertrophy. Exogenous androgen exposure can suppress endogenous regulation and fertility despite high circulating concentrations.