GLOSSARY

Genomic Androgen Signaling
Genomic androgen action regulates transcription through androgen receptor-associated complexes.

Production, transport and local action. Androgen action depends on central gonadotropin drive, gonadal production, binding proteins and tissue-specific metabolism. Conversion to DHT or estradiol changes the local signal. Receptor expression and cofactors determine how exposure becomes a response in each organ.

A distinction that matters. Genes can be activated or repressed depending on regulatory context, with protein changes developing over variable time scales.

Interpreting androgen status. Symptoms, repeated appropriately timed measurements and relevant LH, FSH and SHBG results help distinguish endocrine patterns. A transient exercise-associated change does not predict hypertrophy. Exogenous androgen exposure can suppress endogenous regulation and fertility despite high circulating concentrations.