FGF23–Klotho Signaling
Hormonal Regulation of Calcium, Phosphate and Bone
FGF23–Klotho Signaling
FGF23–Klotho signaling reduces renal phosphate reabsorption and modulates vitamin D metabolism.
Three organs in communication
Calcium and phosphate regulation coordinates intestine, kidney and bone through PTH, vitamin D-related signals and FGF23. Ionized calcium, renal function and tissue responsiveness influence the pattern. Serum concentration alone does not measure skeletal mineral stores.
A distinction that matters
Renal function and receptor machinery influence the resulting phosphate-regulatory response.
Bone under load
Mechanical loading supplies local signals that interact with endocrine state, adequate energy and nutrient availability. A circulating bone marker can reflect several skeletal sites and does not independently prove stronger bone or predict fracture risk.
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