GLOSSARY

Exogenous Testosterone and HPG Axis Suppression
Exogenous testosterone can reduce hypothalamic and pituitary stimulation of the testes through negative feedback.

Therapeutic effects and feedback

Endocrine medicines can replace deficient signals, activate or block receptors, or change hormone synthesis and metabolism. Physiological replacement differs from supraphysiological exposure. Dose, route, duration, comorbidities and feedback suppression influence both benefit and harm.

Specific considerations

• Lower gonadotropin support can impair intratesticular testosterone and spermatogenesis even while circulating testosterone is elevated, and recovery after stopping is variable.

Clinical and sporting context

Legitimate treatment and anti-doping eligibility are separate questions. The current prohibited list, route-specific rules and applicable TUE process must be checked through official sources. Mechanistic descriptions should not be used to design unsupervised performance-enhancing drug protocols.