Decorin as a Myokine
Myokines and Skeletal Muscle Endocrine Signaling
Decorin as a Myokine
Decorin is an extracellular-matrix proteoglycan investigated as a muscle-derived signal.
Evidence for muscle-derived signals
A candidate myokine requires evidence of muscle production and release. Endocrine action additionally requires biologically relevant delivery and a response at a distant target. Expression within muscle or an increase in blood alone does not establish this entire chain.
Interpreting the mechanism
Its interactions with growth-factor pathways do not establish a proven human hypertrophy supplement target.
Interpreting exercise studies
Sampling time, muscle damage, other tissue sources and assay specificity affect measured exerkines. Animal or cell findings can identify mechanisms but do not guarantee a proven human performance benefit. Local action may be important even without a detectable circulating rise.
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