GLOSSARY

Analytical Sensitivity and Specificity
Analytical sensitivity describes the ability to measure low concentrations, whereas analytical specificity concerns distinguishing the intended analyte from interfering substances.

Separate biological and analytical effects

Hormone results depend on secretion rhythms, binding, clearance, sample handling and the measurement method. Reference intervals and decision thresholds serve different purposes. Assay-specific interpretation is especially important near low concentrations and when results conflict with the clinical picture.

Interpreting the mechanism

• These differ from clinical sensitivity and specificity for diagnosing disease.

Define the testing question

Dynamic tests examine a regulated response under specified conditions. Their protocols, contraindications and thresholds require clinical oversight. A glossary explanation supports understanding and does not provide a self-testing or medication-adjustment protocol.