Adipose Endocrine Dysfunction in Insulin Resistance
Adipose Tissue, Adipokines and Appetite Regulation
Adipose Endocrine Dysfunction in Insulin Resistance
Adipose endocrine dysfunction can combine altered adipokines, inflammation and impaired lipid handling during insulin resistance.
Adipose tissue sends information
Adipose tissue contains adipocytes, vascular cells and immune populations with distinct secretory contributions. Depot, energy status and inflammation influence the resulting endocrine profile. A circulating association does not establish the producing cell or prove a causal metabolic effect.
Specific considerations
Correlation with one adipokine does not prove a single causal mechanism.
Appetite is integrated
Hunger and food intake reflect endocrine signals together with neural reward, meals, sleep and environment. Low energy availability can occur at different body sizes. No single adipokine concentration can independently determine an athlete's fueling requirements.
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