5α-Reductase Type 1
Androgens and Male Reproductive Endocrinology
5α-Reductase Type 1
Type 1 5-alpha-reductase has a tissue distribution and substrate profile distinct from type 2.
Production, transport and local action
Androgen action depends on central gonadotropin drive, gonadal production, binding proteins and tissue-specific metabolism. Conversion to DHT or estradiol changes the local signal. Receptor expression and cofactors determine how exposure becomes a response in each organ.
A distinction that matters
Its contribution depends on the steroid and local physiological setting.
Interpreting androgen status
Symptoms, repeated appropriately timed measurements and relevant LH, FSH and SHBG results help distinguish endocrine patterns. A transient exercise-associated change does not predict hypertrophy. Exogenous androgen exposure can suppress endogenous regulation and fertility despite high circulating concentrations.
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