GLOSSARY

The fibroblast is the most common cell of connective tissue; it produces and maintains the components of the extracellular matrix, especially collagen, elastin, and proteoglycans.
These cells are usually spindle-shaped and are abundant in tendons, ligaments, fascia, skin, and joint capsules; tendon fibroblasts are also called tenocytes.

Function

By continuously building and breaking down fibers, fibroblasts remodel the matrix and respond to its quality.
These cells are sensitive to mechanical loading; appropriate stretch and load increase collagen production, while prolonged immobility reduces it.

Role in Repair

After an injury, fibroblasts migrate to the damaged area and first produce disorganized, weaker