Active Hormone
Endocrine System and Hormones
An active hormone is the form of a hormone able to bind effectively to its receptor and produce a response in the target cell; many hormones are converted from a prohormone to the active form after secretion or in the target tissue, and only their free fraction (not protein-bound) is active.
Examples
- T3 (active) versus T4 (prohormone); T3 is about 3–4 times more potent.
- Calcitriol (1,25-dihydroxyvitamin D) versus calcidiol (25-hydroxyvitamin D).
- Angiotensin II versus angiotensin I.
- DHT versus testosterone (in certain tissues).
The Free Hormone Hypothesis
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